Driving with camper windows open?

We have had the camper for 4 months now and it has worked well. With the weather starting to get warmer and the sun showing up around here I was wondering about traveling with some of the windows and/or vents open in order to keep the camper cool. Does anybody have any experience with this? Are there any downsides to this? 60 mph winds in the camper or getting a lot of dirt in the camper going down dirt roads?

Specifically I was thinking about opening the pass through window with one or two of the top vents (both have max air covers on them).

Thanks