I agree with ktmrfs as speed doubles wind drag squares.
Want more horsepower ? burn more fuel.
A 3.5 ecoboost with both turbos open pushes 6 liters of fuel and air through the cylinders, and will burn an appropriate amount of fuel. It's not the motor, it's what you are asking it to do. No 5.0L can make the same HP on less fuel. Common sense. Fuel = HP. Which do you want ???
My ecoboost gets over 30 mpg cruising in the 40 mph range with cruise on. Ever see that out of a 6.2L ?
Having a v6 and listening to it purr at 1500 rpm at 65 MPH with cruise and tow haul on for hundreds of miles gets, almost, boring. Never needs to shift out of 6th (second OD ). Had dozens of trucks but, nothing that pulled like a diesel with the economy of a gasser. YUP, I have owned a diesel truck, the turbo ecoboost pulls a lot like one.