I wouldn't hesitate with that rig. My V10/4R100 has 402,000 miles with no major problems. I've had some age issues with the cooling system... Burst radiator and some burst heater hoses. I did have a couple COPs fail after 300k so last year I swapped them all out preventatively when I did the plugs. Starter relay goes out about every 100k (easy to bypass when it does). Serpentine belt idler seized on Christmas eve, but I was able to limp to a safe place off the highway on 5-cylinders.
Really, on a 2005 Ex, your biggest problems will probably be front-end wear, as it shares the '99-'04 pickup hardware, which tends to eat ball joints and sometimes unit bearings by that many miles. However, being a V10 you might be able to get some extra life out of those parts vs a diesel.