F 250
the 4 disk brakes are bigger and better ventilated on the F 250
the usable payload is much better on the F 250
trailer sway is increased with a lighter percentage of tongue weight .
the F 250 rear axle payload is much greater which allows one to carry gear , passengers , in the pickup and still have enough left over to use 13 % plus of tongue weight .
the f 250 will have a longer service life because the brakes , driveline , transmission , and radiator have reserve capacity keeping them from being overloaded .