We have an extended cab Ford F-250 and we do several long trips each year, but we will only drive 5-6 hours at a time. 300-400 miles is pretty much our limit and we have no real desire to drive more than that. Pull in, put out the jacks, plug in, extend the slides and hit the pool. In the am, bring in the slides, pull up the jacks, unplug and take off.
If we don't have enough time to stop and spend the night, we don't go or don't plan to camp. It is just too much for DH and I, plus the girls (11 and 8) and we just won't do it.