If the 6L90 can handle 556 hp and 551 lb-ft in the CTS-V or 580hp and 556 lb-ft in the ZL1 on the track, then I think it can handle what a 6.0L 2500 can put out unloaded. According to GM Authority spec sheets on the 6L90 the max horsepower it can handle in a gas truck is 452 hp and 531 lb-ft which is far from what a 6.0L will be able to achieve with just a tune.
Having worked for engine/auto manufacturers and being involved in testing, I can say the public assumption/perception of why things are the way that are, and the real reason as to why things are the way they are often are not the same. Also, what may have been the case decades ago may not still be today.