Kind of curious, are you looking at a brand new truck? The cost of a new F250 optioned out nicely is pushing about $55k+ and I'm guessing a recently used F250 might be in the $35k range from a dealer? Also, it is a bit unclear but do you already own the camper or is it a deal you are looking to make?
Having owned a 2000 Lance 1170 for four months (I bought the truck and camper together), I got rid of because I found extensive dry rot. Initially I tried fixing it to the tune of $3000k but even after that I found more dry rot in other areas so I gave up and sold it. Not a hit against Lance by the way, just repeating my experience.
I don't think there is anything inherently wrong with a wood framed camper if they are maintained well and sealed properly but they are not very forgiving if abused. In my case I knew I was driving thousands of miles each year and I was concerned about the frame flexing and opening cracks in the seals so I went with the fiberglass Bigfoot 2500 which was significantly lighter and better suited to my needs.
Unless you already own the camper I would take a look on Craigslist to see if you can find a package truck and camper deal. They come up periodically and a lot of times the previous owner has invested significant money into the truck already to get it ready to carry the camper.
Finally, though a Single Rear Wheel truck is capable, if you go used I would HIGHLY suggest making a Dually a priority. The load carrying aspect is a factor but I feel more importantly the stability factor is a huge factor to consider. Campers are top heavy and having that extra width is reassuring.