It can depend on the trailer. Some have very little in the way of exterior and interior storage. No pantry, no overhead cabinets above the dinette or sofa, small front cargo openings, smaller fridge, etc. You get the point. The on the flip side and you're packing more than you think. Some people just use their $30,000 TT as a tent on wheels, packing very little and staying in full hookup sites while eating out at local restaurants. Others dry camp and take a lot of gear to accommodate the lack of services.
IMO 200-400 lbs one way or the other shouldn't make a difference.