Via Water heater bypass line (connects cold inlet line to water heater with hot outlet line from water heater---if you have a bypass)
Otherwise....have to fill water heater with 6-10 gallons of anit-freeze (depending on size of WH) before it will flow to hot water system. And then you have all that anti-freeze in your WH...waste and don't fire off WH with it in there.
Best to bypass WH. Install a bypass if you don't have one.