The need for a low or high number rear gear ratio boils down to how the truck is being used and how often. If it is unloaded most of the time and you occasionally tow closer to its max ratings then it is probably best to get a lower number rear gear ratio and just select lower trans gears as needed when towing. If it is towing most of the time then it is probably best to get a higher rear gear ratio.
Getting a lower rear gear ratio to get better fuel economy on a truck that is towing 75% of the time makes no sense just as getting a higher gear ratio for a truck that is unloaded 75% of the time it is used.