Observing engines efficiency was always my hobby and also boredom killer when I cover long distance.
Each engine has it "sweat spot" and you have to find it on your own as no publications will give you that.
Modern engines pull strong at 1000 rpm, while 1200 rpm gives them good torque for hills climbing.
I am talking diesels in case you did not notice ;)
My 6.7l Powerstroke cruise 60 mph at 1600 rpm and it is good for pulling 8000 lb trailer on 14 miles steep grades I am facing whenever I go on West Coast.
I can only wish I could get lower differential ratio as after all those years of playing with gears, now pulling heavy set on steep grades without downshifting just doesn't sound right.
With gasoline engine you have to observe pinging. Modern engines will adjust timing to protect the engine, but that leads to less power, gear shifting and whole Hell break loose.
When I was driving gasoline car - going across Sierra I always filled with Premium to avoid the hassle.