Having been there, done that, areas you need to consider.
Lift effect on driveshaft. Steeper angles result in higher probability of failure as does the taller tires which mean more torque required to get things rolling.
Taller trucks have more has more sway, roll etc which a trailer can amplify and cause handling issues with.
Taller tires = higher effective gear ratio putting significantly more stress on engine, and drivetrain. Effectively lowers vehicles towing ability a great deal. You have to consider engine and transmission heat dissipation abilities. Also, a tire being basically just a lever, while braking your taller tires require a great deal more of the discs for stopping. Trailer brakes being less than ideal most of the times you may find the brakes to be lacking, especially on a steep decent.
Finally, look up the difference between floating and semi floating axles. It's worth learning why heavy duty trucks use the axle they do, and why increasing the probability of axle failure on a half ton in particular which generally has a semi floating axle might be something you're not willing to risk. Taller tires with high power demands have resulted in my snapping two axles over the years while off roading.
Personally, I think you'll run into more issues with your drivetrain an pulling than you will with load. Either way you're pushing it. How negative the effects will be is hard to say.