The derated versions in Navistar and even the Ford vans and chassis cabs had less issues. This is why the ones with the pickup tune should not be run with an aftermarket tuner unless you also plan to upgrade a significant amount of the engine to support even more output.
My 6.0 pulled everything I threw at it even when traveling in the Rockies, so I never considered aftermarket hop-up parts. It does like to rev compared to an inline, but it had no problem breaking the rear tires loose when it used to tow my toy hauler.