A few comments: I believe that a good way to minimize problems is to install extra capacity. I have read on line (therefore it is true) that tires that carry passengers (such as LTs) are required to build in extra capacity. Comparing an ST to an LT of the same size and load ranger, the ST will be rated at more lbs. So, when moving up in size or load range in an LT to get the same capacity as an ST, you actually get some hidden capacity. Also, as mentioned above, until recently all ST tires were rated at 65 mph. LT tires would be rated for higher speeds (such as 96 mph) which again provides some built in safety margin when driving at 65 mph.
10 years ago after my OEM China Bombs started separating, I switched to Denman tires because this forum liked them as made in North America. After blowing one when a spring broke, and then blowing another just driving down the road, I switched to Maxxis. In fact I put my son's trailers on Maxxis as well. None of those tires ever had a problem, and 6 years later none of them showed any dry rot.
Being concerned about speed ratings, I tossed the OEMs that came with a new trailer 6 years ago and switched to LTs. Since I needed additional height, I purchased 16" wheels to get into 16" LTs. While also going from D to E range, I added additional tire capacity, not to mention the hidden capacity in the LT. I had zero problems in 6 years.
On the third trailer purchased this year, I immediately pulled the OEMs and replaced with Goodyear Endurance. When compared with most STs the Endurance weigh more and have an 87 mph speed rating. They have been just fine so far. The Endurance also come in both 235/80R16 and 235/85R16 so moving up to the taller tire gave me about 200 lbs. per tire additional capacity.