I just made a 2000 mile trip, and diesel is easier to fill with a large trailer. I discovered that diesel at the truck pumps was also more, and you had to go in an prepay unless you have a credit card set up for $500 at gas pump. I used the truck lanes when I needed DEF, and used the other pumps when I did not need DEF. Most of the truck stops along the freeway were easy enough to get into with the trailer without the using the truck lanes.
If this is going to be your travel vehicle, I would buy based on seat comfort. The LTZ power seats made the ride much better for me.