At the north end of Delaware, do not take Route 13 through New Castle as some GPS suggests - stay on the Route 1 expressway all the way to I-95. That stretch of Route 13 is a nightmare with traffic lights.
To change things up south of Dover, sometimes I'll take Route 113 as opposed to Route 13. While Route 113 swings further east and is slightly longer, I remember there being less towns with traffic lights. The two roads come together down in Pocomoke City, near the MD/VA border. And then it is Route 13 to the bridge/tunnel.