Our trucks at work (older ones now-- '05'08 era) have Cummins ISM engines and seem to have a fair amount of EGR issues. Few older ones yet have the ISX and no EGR's and no issues. Newest ones '12 and up have Detroit DDT 13's w/ DEF and while the engine itself is quite durable, the DEF side of things have been a pain. But when they work right, all is great. For the most part overall, cannot really say the DEF systems have set us back. I know awhile ago I stopped at local semi dealer's service dep't to ask a question and they told me that 70% of trucks in yard were DEF related problems. IMO, the trucks that get ran the hardest seem to have the least amount of issues. Those that start/stop/shut off often are the problem children.