You just have to keep an idea of what to do on the road. Such as transmission... do you get a Jasper exchange, OEM rebuild, or just stop at the local rebuilder? No right or wrong just don't get caught not knowing what to do.
At 140,000 review the rubber parts like hoses, belt, bushings etc for soft spots, cracking etc. I would not just tear into things but if you need coolant replaced consider doing ALL hoses. Or if you need brakes be sure to do a fluid flush and maybe brake hoses. Just go a little extra when you do need work especially if doing it yourself.
190,000 on my truck and I have replaced on the road a battery, fuel pump, and an alternator over the years. All seemed to work out OK with not too much disruption. I would not hesitate to take my truck cross country.
