Each engine has its "sweat spot" when it delivers best mpg and each time I drive 40 mph highway my mpg will skyrocket, but who wants to drive that slow?
Me! I love to get on the back roads without traffic and run this slow. The adventure to me is getting there and driving slow allows me to enjoy the scenery along the way. Please note - I did say without traffic as I know most folks won't.
I sure wish I could get 24 on the highway with my 1-ton running empty at any speed. Running 75, I would only get around 16 if it was pure interstate. Running 65 I only average about 18 if the traffic is heavy and flowing. Now hauling the camper I can get about 13 on the interstate. But my average after 35,000 miles with the camper is 12.3 mpg (hand calculated).
One of the things is if you are using the overhead computer or hand calculating the mileage. I know with my lie-o-meter, I'm about 15% off when running empty but usually only about 8% off when running with the camper.