We have had slides for years with out any problems to speak of. We sometimes leave a campground in the very early morning 4:00 am. We will just leave out our bedroom slide or maybe the slide with the dinette depending on the weather if it is cold and want to heat the trailer.
We often remove everything except the chocks and hookup is we disconnected. In the am we just make coffee and bring in the bedroom slide.... on the road in 20 minutes max.
Our unit is a 3 slide unit and I overnight without even leveling.
These trailers are in the most part developed enough to do most anything without problems just don't try to drive down the road with them out, LOL