So, if you were switching gears from a 3.73 in an Excursion with the V-10, would you go right to 4.56 or 4.30? Gas mileage is not a concern, and it's in a 2WD.
I wouldn't hesitate to put 4.56 gears in with that engine, especially if you have the older 4 speed auto. I used to have a motorhome with the V10 with 4.63 gears and smaller diameter tires than your Ex, and while mileage was not great running 17K combined, power was decent and it never felt like it revved too high on the freeway.