So, if you were switching gears from a 3.73 in an Excursion with the V-10, would you go right to 4.56 or 4.30? Gas mileage is not a concern, and it's in a 2WD.
calc the highway rpms you'll see at top speed when running empty and see if you're good with cruising at that rpm and let that make your decision on final gear ratio.