We have a 38 foot 5th wheel and a TC. We use the TC for most trips and leave the 5th wheel at campgrounds as a seasonal home base, either here in VT or in FL, where it is now located.
Backing up with a trailer just takes practice and patience. No big deal. And as far as space and cost per square foot there is no comparison. The 5th wheel wins hands down.
The TC works for us (no slides, Northtstar Igloo 9.5) and I personally don't want slides and the associated inconvenience of weight and loss of heat in winter. If you can't fit into a TC without slides you really need to consider a DRW truck. We are able to make it work with a SRW and have over 30,000 miles with lots of smiles and no issues.
So you are really asking to compare apples and oranges. Each mode has advantages and disadvantages. You need to decide what is most critical for you and then you can make a decision on trucks and brands of campers.
Not much help I'm afraid but since we have both I can speak from experience.