100% of the newer big rigs and commercial trucks with diesel engines are setup for DEF. With passenger cars there is an effort to develop a new type of direct injection that will meet emissions requirements but these require a very special filter so at this time they put out 100x the emissions of a standard diesel and another magnitude more soot and NOx than the DEF equipped trucks.
Figure on about a gallon of DEF for every 1000 miles you drive and 750 miles when towing and you will be in the ballpark. DEF is actually good at minimizing soot buildup in the crankcase motor oil which is why it is considered a good thing by fleet operators who are professionals.