3.5L Ecoboost in an F150 is a great option. They make way more torque at much lower RPM than any of the V8's offered from any manufacturer.
I haven't driven a RAM 1500, but just note that since '13 they have been an all coil spring suspension. This is a positive!!!! My '14 Ram 2500 is all coil spring and despite how huge the truck is, it's the smoothest riding HD truck I've ever been in. I would imagine the 1500's ride just as smooth or maybe even better. Also, I don't have experience with the RAM box, but I think that could be a really useful feature.
Aside from those differences I would guess the real difference comes to price, features, and your personal taste.
KJ