I had them on my 2010 Tundra. Granted the truck was a lot lighter than your F250, the tires were fantastic. Lasted until I traded my Tundra with a little over 60K miles and there was still tread left. Load range E provided a very stiff sidewall that was fantastic for towing. Aggressive tread gave me good traction in snow, light mud and wet grass. Tread was still pretty quiet on the highway and gave me great highway traction as well.
I was very impressed with the tire and had no complaints at all! Again... my truck weighed a good amount less than yours, so your tire longevity will probably not be as good as mine was. Still... 60K miles and still had tread left. That made me quite happy!