No to anything other than the original ST tires or LT tires along with appropriate rims. You might want to go up one load rating (LRC to LRD) and use better quality tires.
Most travel trailers come with ST trailer tires and it is critical to stay under 65mph and to keep them inflated to the correct psi at all times. Ignoring either causes overheating of the internal tire structure, irreversible damage and will result in tire failure. Avoid potholes. Stay off shoulders where you could pick up something that will cause a puncture. What is the weight of your TT versus the total tire load rating? You want a 20 percent or more safety margin but some manufacturers load them up close to their rating. The weight can vary from side to side too which can unknowingly overload tires on one side.
Are you having punctures, "blowouts" or tread separation? In the occasional case, the axles can be bent (owner caused) or misaligned (factory caused) causing uneven tire wear and eventual failure.
Many RV owners use a TPMS to monitor tire pressure in their RV. Some (like me) check tire pressure on each leg of a trip before heading off. We have made in China Goodyear Marathon load range "D" tires with 10,000+ miles on them over 2 season with no problems - factory normally installs ChinaMaster LRC tires.
Lots of excellent reading on
this blog by a former tire engineer.