Not sure how the F150 stacks up, but we're pulling a similar TT with a Tundra. The truck does quite well with it - have been up & over mountain passes, etc. If the Tundra weighs significantly less than the F150, you might be happier with the latter in windy conditions. However, the Tundra has plenty of engine for this trailer. As someone else described it once, "more engine than truck," and I tend to agree. LOVE the 6-speed tranny & engine "braking". As to mpg, our truck gets about 8-9 mpg towing, on average; 15 mpg around town, 19 or so on the road when not towing.