I have never had a bad experience driving but have mileage drop as much as 5 mpg fighting the wind yet never seen that much added when we had a tailwind.
We had a tent camper at one time. Rain was blowing sideways at about 50 mph so I sent DW into truck as I faught the wind in the middle of the night to close up the trailer.
Traveling through the plain states with our toy hauler there was high wind advisory and it was getting late. I pulled into a service station lot nose to the wind and DW could not open her door due wind streaming around the front of the truck. Being twice her weight I was able to open her door but once she stepped beyond the door's edge, she almost lived Dorthy's tale (yes, she had one our dogs in arms at the time). I only dropped the tongue jack and kept everything else connected in case we had leave suddenly. Two tornadoes passed within 50 miles of us that night but we slept through those warnings and did not know about them until morning.
We desert camp a couple times a year. I always nose into the wind to prevent having a large side that could become a sail. I have not seen trailers or campers turned over but have seen bent leveling jacks and missing awnings due to winds.
With the TC having the rear door, it makes nosing into the wind even more convenient but it is not always possible if you are in campground. If I know winds are higher, the TC stays on the truck and the legs are dropped to avoid rocking (unload the truck suspension by 1/2").