I have actually read a similar conversation a long while back but not sure in which forum, tried a search here but unsuccessful. So, I took the newly delivered truck (Sierra 2500) for a break-in ru...
"2019 2500HD with the towing mirrors. At certain speeds and wind direction the mirrors whistle. If I extend the mirrors out a little, it stops."
Several years older model with the same issue. Pull the mirrors out just a bit (.5" or so) and it stopped. 13 years later, apparently enough crud has built up that it doesn't happen anymore.
Had the same noise issue on a Toyota Tundra: fixed by putting a strip of black electrical tape over a seam in the mirror housing.