IMO, the slight difference in ratios of these modern trucks is one of the more over-stated things that gets talked about often. Slowing down 1mph would likely save far more fuel than the ratio change. And, with these modern transmissions even the most experienced driver would be hard pressed to notice any difference.
Sure, if you're ordering a truck, get the ratio that fits your needs most closely.
The Ram message board I hang out on had some guys go from a 3.73 to a 4.56 and they all love it. Some even reported BETTER mileage around town. I can understand a change that significant but the slight 3.73 to 4.10 is pretty minor.