Assuming you are looking for better fuel mileage?
I don't know of a way to calculate the stress you will put on the camper.
Just my opinion but the small gain would not be worth the possibility of doing expensive damage to the camper.
edit add...I'm not understanding the oversized predrilled holes. Will you be pulling off the interior wall covering to put washers & nuts on the interior sides of the bolts? If so, making the holes oversized would reduce the holding power of the bolts. Or, are you thinking of just screws with no nuts?
If I was going to do something, I would think about a spoiler mounted on the rear of the roof to reduce the negative pressure behind the camper. Maybe bolted to a luggage rack, not screwed in the roof.