Best Route Nashville-Branson

If your map software tries to send you through Little Rock, be aware that there is considerable construction between Memphis and Little Rock. I would take I-40 to Jackson, TN, then pick up 412 and stay on it all the way across the MO bootheel and North Arkansas until it joins US 65 at Harrison, AR. Just north of Harrison, 65 leaves 412 and goes straight to Branson. Not a lot of four-lanes on this route, but adequate passing lanes and lots of scenery. Have a great trip!