I've deleted all the unkind and irrelevant responses.
Yes, the OP could have provided a few more details, except for the fact that this is basically an 80 mile stretch where you either go through or around Cincinnati. There truly isn't room for much nuance in the question of "what's the best way to get from here to there?"
Based on the locations of most of the responding members, I'm going to guess that most of you don't really know and didn't even read the choice of roads that were mentioned anyway.
It's rare to get so many troll responses to a thread in Roads & Routes, but maybe this is another sign of the brave new world that we've found ourselves in.
Please though, let's please keep the responses kind and on topic. And if you have nothing constructive to offer, then by all means please just keep scrolling.
My own two-cents for the OP are that Google Maps shows a third option that kind of threads the needle through both of the routes that you mentioned. It's a smaller road, but it looks like a quick route. We didn't drive that route, but we've driven through a lot of those roads and we found them all to be pretty and pleasant drivers. Good luck on your trip.
And maybe someone who's more interested in being helpful than looking smart (incorrectly so) will add their useful comments.