Did it just a couple weeks ago. Use lower gears for going downhill and keep off the brake. Big trucks usually turn on 4 way flashers and move over to climbing lane to stay out of the way. Stop at Ferguson's at St. Joe for a good cup of coffee and cobbler. Enjoy!!!
You should have no problem at all. Many years ago, 65 from Springfield MO, to Branson, and then into Arkansas was two lane. You will find many sections with extra lanes. 65 will take you to I-40 at Conway.
I see them almost every day 3/4 of the year and have been behind many up and down Highway 65, never have seen a problem. There are plenty of passing lanes, so taking your time of you feel the need is not a problem.