I will be coming from Columbus Oh, entering Charleston area via US-35 to I-64, I plan on getting on I-77 / I64 heading south after crossing the river, then continuing onto 60 (Hwy 60?, I-60?) at Exit 96 towards Belle, and continue on towards Lewisburg, WV.
First, I much prefer secondary roads to the interstates. Traveling east from KY to VA, I took the US 60 route above in our 26 ft Class C. We wanted to see the New River Gorge bridge. Pros, scenic route Kanawha Falls, Cathedral Falls, and New River Gorge Bridge. Cons, curves and hills. In 4 seasons and 30K miles of driving the Class C, that was the most tiring drive I have had. I would drive in a 30-35 MPH crosswind in South Dakota again over that drive.
If traveling in that area in the future, I will pay the tolls and make better time and stay on I-64.