Cincinnati I74 to I75 SB

We travel that route often. We take Highway 9 out of Pendleton and hit 74 Southward to Cincy. We never go the downtown Cincy route. Take the 275 route, then hit 75 going on South. You'll find it much more enjoyable, less traffic, less congestion, and you'll never know you are actually circling a large city. It's all country interstate driving. You'll come in and out of Indiana about 3 times. We always get a laugh about that.

If you want a bit of a scenic journey, from I-74, take Highway 1. It dumps into 275. It will cut several miles off your route, but it's also slow driving through small burgs and such. But, it's really a pretty drive.