We have travelled I75 through Cincinnati many times on our way South for the winter, back North in the spring, and always went straight through instead of taking the bypasses. We have never had a single problem doing that way. The bypasses add a lot of time and miles to the trip.
We did try the West bypass one year and did not have any problems but it is a long way around! I don't remember what the road was like or how the truck traffic was since it was so long ago. Probably not much help but is the best I can do right now. Good luck. :)
Barney