Has anyone taken the Hwy 385

I do every road I can at least once unless a DOT says I can’t.

A little hilly. Grades are easy. Not mountainous, in SD from Hot Springs to Neb. state line, 4 lane. Also, I'm not aware of aplace called 4 corners along US 385 from its start in Deadwood SD south into Co.
OP , double check on which forum you post your question. You should have posted in roads and routes , not forum help. A moderator will likely correct it for you.

You are going to encounter real mountain highways on your way to Four Corners. Not on 385 but I-80 up to Four Corners is confusing. Four Corners is at the extreme SW corner of Colorado. More information please.

As previously said 385 no problem. Nice very short side trip that I thought was interesting was the Museum of the Fur Trade in Chadron NE just a few miles east of town. Another one if you just need a short break from driving is CarHenge in Alliance Nebraska. We were passing through and saw the sign went and checked it out since we were looking for a place to take a break anywayn. Sort of like the largest frying pan in the world type of thing just odd

Thanks, looking for side trips to take out 9 yr. old granddaughter. We did the trip 9 years ago with our grandson, now it’s her turn, he was into motorcycles so took him to Sturgis but she’s not, the large frying pan she would get a kick out of. We went from South Dakota to Estes Park then down, awful roads thru mountains, but she’s not into that, so going straight down. Different route than we took with our grandson. if anyone else has any tips, we would sure appreciate it. Thanks

There are no awful roads thru mountains. Especially on motorcycles.