If I was driving this route, I would take I-40 to Ashville, NC, then I-26 to Spartanburg, SC, then I-85 to Commerce, GA, then US Hwy 441 to Madison, GA, then I-20 one exit west to GA Hwy 83, then pick up I-75 at Forsythe, GA.
This route misses Atlanta, and has by-passes around Athens, GA and Madison, GA. There is some road construction around Greenville, SC. The two lane roads are often 4 lanes, and many times are 3 lanes. All are excellent roads with little traffic, and as a plus, the towns have great eating places and are very interesting.
Around Ahens, GA is a loop that can be a little confusing. It is marked GA Hwy 10 Loop and is also US Hwys 129 and 441. JUst get on the Loop and then the signage is plain.