I did the Cincinnati to Fairbanks trip over 10 years ago, crossing into Alberta, Canada at Sweetgrass, MT.
Expect potholes. A little crack turns into a big crack when the crack fills with water and freezes. The traffic turns the big crack into a pothole and the road crews spend the short summer temporarily fixing them. Fact of life.
If you expect hookups, better do your homework first. CGs with utilities are rarer than in the states once you get past Edmonton. Such a short camping season. Oddly, I found some CGs with just 20A and 50A. No 30A. So take dogbones if you run on 30A.
Miles/Kilometers per hour are on your speedometer, but bridge clearances are in Meters. Make a cheat sheet, or at least know how high your rig is in Meters.
Convert some $US to $CN at your bank before leaving home. Once you're a couple hundred miles north of the border, don't expect businesses to know the conversions.
Tim Horton's is the Canadian Starbucks, and they're everywhere.
Don't worry about gas even though its sold in Liters per $CN. They pump the gas for you - no choice. I walked into a deli to buy some lunchmeat and it was priced in $CN per gram. So I just ordered 8 slices, but that's a nice cheat sheet to have as well.
Finally, read the customs regulations before you leave home. Example: No handguns - period. Same thing returning, except its food items. Mostly fresh fruit.
Do not lie to the customs officials as you cross the border. I saw some poor soul taking everything that wasn't permanently attached to his RV and spreading it out on the ground. The Canadian customs official asked me if I'd ever been fingerprinted. I told him maybe when I went in the Navy, but I wasn't sure. My index fingerprint was on the passport - duh.
OTOH, clearing customs into AK and back into CN, I barely had to slow down before being waved thru. Same returning to the US at Sweetgrass. But don't count on it. Be prepared.
One other thing. Once I got past Edmonton, there were days where the only thing I saw on the road were animals. Alive, but in no hurry to cross.
Trip of a lifetime.