Your biggest concern will be 65 from Chicago to Indy. It is often pure madness driving 85mph to 0 and back to 80 often. This stretch is notorious for major accidents, back ups and yes even deaths so be alert.
In Indy it depends on the time of day what route you want. Rush hour I would go straight down 65 to 70. There can be some pretty good back ups at the 465-69 interchange on the North side during rush hour. Any other time I would take the north route you referred to as 52. You will find it will be labeled as 65 to 865 to 465 East which will turn to 465 South as it starts to go down on the South east side to 70. It is one continuous loop that changes numbers as it loops from east to south.
70 from Indy to Dayton has some construction but most areas have 2 lanes open and back ups are minimal. From mile mark 130 to the Ohio line (mile mark 156) there is night and weekend lane closures that chokes traffic to 1 lane and creates some long back ups. You will find very heavy truck traffic and rough roads from Indy to Dayton.
i hope this helps.