Many thousands of RV's make that drive every year. There are plenty of videos up on Youtube showing them doing it. We've done it multiple times.
As for the trip to Bluff, we've been down all tree of those roads. I90 of course has no surprises, there is some interesting scenery are Grand Junction if you haven't been that way before and Colorado National Mounment which is worth no more that a drive thru with a short trail or two along the way.
Cortez to Monticello no major surprises there, we camped for a week in Cortez and then moved up to Monticello for another week of exploring that section of Canyolands.
90 is a two lane highway, the most interesting part of the trip is the way to Naturita. The southern route runs thru a series of tall mesas on each side of the road but mostly to the north. This was Uranium country, with a 4WD you can drive up to the top of the mesas and see old mines. There is still a lot of acreage marked off with Dept of Energy signs and you will see fresh diggings so mining is still going on I guess. The most interesting road tho is the northern road that runs thru Gateway and back to the highway. It is extremely scenic and could be called a mini-Grand Canyon or Zion. Apparently there are campsites and trails up on the mesas. We went thru right after a rain and there we many small waterfalls running off the mesas.
Arctic Fox 25Y Travel Trailer
2018 RAM 2500 6.7L 4WD shortbed
Straightline dual cam hitch
400W Solar with Victron controller
Superbumper