Yes, I have experience with this route all the way from Waynesville, NC to Murphy, NC -- many times in auto and a few times towing a fifth-wheel. I've always enjoyed it, especially through the Nantahala National Forest. Just don't be in a great hurry. Don't know what else to say except that this would be my route of choice between those two towns in North Carolina. We've been going to Western North Carolina since the late 1950s: Whittier, Dillsboro, Sylva, Cherokee, Bryson City, Lake Junaluska, even Asheville.