Take I-295 East around Jacksonville. To avoid Atlanta and Jacksonville, Take I-40 to Ashville, NC. Then I-26 to Spartanburg, SC. Then take I 85 South to Commerce, Ga. and then take US 441 South. Through Athens, Watkinsville, onto Madison, Ga. Take the US 441 bypass around Madison to I-20. Take I-20 west one exit GA 83 South. Take Ga 83 South through Monticello to Forsyth, Ga. and Get on I-75 South. Take I-75 South to I-4 South in Orlando, and then US 98 to Wauchula. These are all good, wide roads, well marked, and will easily accommodate your 5the wheel. There are plenty of places where you can refuel, stop for meals, and even a few RV parks and state parks close by as well.