We did this route last summer towing a 7600 lb TT and it was fine. A good road but very few service stations other than the towns. Two watch-outs:
1. In Cortez there is a screwy Y-shaped intersection. From Moab to Durango you will be coming in on one of the legs of the Y. The tricky part is that the road goes from 4 lane to 2 lane in the intersection with no warning. We were actually crowded out and had to jump a curb to save the sheetmetal.
2. As you come into Durango on 160 there is a very long and steep downhill grade - The Mountain Directory West lists it at 4-5 miles of 6%. It's manageable in lower gear, but the hill just goes and goes with several gentle curves. Take your time.
2013 Tundra, 5.7FF, TRD, 4WD, tow pkg
2014 Forest River Cherokee 264
Prodigy II / Equalizer 10K
103 nights & 12,700 miles since April '13