We've done this the both ways. Going south we stop at the Fredricksburg KOA. US301 is an old US road (this is how my grandfather got to FL from NJ), so it's stretches of 55 mph road interspersed with towns with stop lights. I actually enjoy the drive more than hours of boring interstates.
The only thing I don't like about this route is the Gov. Nice bridge crossing the Potomac. According to DelDOT web site, there was a ribbon cutting for the reopening in May, so I'd say it's done.