Also once you get over the pass, I like taking 6 to 95 and coming into Vegas that way. 395 is a good drive too, but if you've done it a lot 6 and 95 is something different. You'll go through some middle of nowhere Nevada, but I love that kind of drive myself.
On Edit: I see the title of your thread is SF to 95 but I didn't see that in your post. So sounds like you are already planning this. I say yes, your rig will make it and it's a very fun drive. It would be a very looong drive to try and do it in a day, but two or more days and it's fine.