School buses and snowplows take those routes, so do log trucks.
Sort of depends on where you are staying near Syracuse and in Lake Placid. There aren't a lot of choices for places to stay.
I'd suggest I90 to Utica then NY12 north to NY28 through Old Forge to NY30 to Tupper Lake to NY3 to Saranac Lake. This is the prettiest drive.
We towed it fine with a 5er.
I lived in that area. They paved and widened all those roads in 1979 for the 80 Olympics, and they seem to have kept them up pretty well.
2019 Grand Design Solitude 310GK
2019 GMC Denali 3500 D/A SRW