I agree with SDbounder and Mikim...skip going through the Los Angeles area. Take Highway 210 in Redlands to I-215 North from I-10 in San Bernardino and take Highway 395 to Highway 58 west over the Tehachapi pass. You'll hit a few traffic lights in Hesperian area but it's a much easier drive than the other way. I just returned from a trip to the Palm Springs area last Thursday. I live off of Highway 101 in Santa Rosa (Northern California). Although, the fires were horrific and devastating for many, they won't affect your trip. Not to minimize the impact of the fires, but the hills are green with grass and your trip will be full of beauty! They've done a great job of clearing debris and there is only a small area that can be viewed closely from highway 101 in the north part of Santa Rosa. It will be a wonderful trip!
Bikendan, we have driven through the fire areas. The road between Calistoga and Santa Rosa (Mark West Springs) was devastated and part of Kenwood and Glen Ellen were affected (mostly adjoining neighborhoods). But all of the quaint towns, wineries (a few were impacted), shops, etc. were spared. In the Napa area it stayed mostly on the hills between Napa and Sonoma. In my opinion, there is no reason to avoid the area.